人类免疫缺陷病毒诱导免疫应答消失的机制
李振,蔡小嫦
摘要(Abstract)：
<正>人类免疫缺陷病毒（HIV）致病过程中,宿主体内的CD4+T细胞数量会缓慢地逐渐减少,当免疫系统崩溃和病毒生长失控时,便产生获得性免疫缺陷性疾病综合征（AIDS）。HIV感染开始时,从病人体内分离出来的HIV群在序列上并无明显区别。而感染期间,HIV通过抗原的变异,进化为复制率更高且对TH细胞更具有致病力的表型,使TH功能的丢失或凋亡会减少细胞毒性T淋巴细胞（CTL）反应的效率,这就意味病毒负荷量也随着不断增加,最终导致AIDS。1 抗原多样性与免疫损伤 在逆转录期由于没有校正阅读机制,HIV在每个基因组及每个复制周期均有相当高的突变率。在高突变率及抗病毒免疫反应的选择压力下,为抗原的进化提供理想的条件。事实上,HIV逆转录的错误
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作者(Author): 李振,蔡小嫦
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