江毅,李勇,覃善芳,郑志刚

• 1:梧州市疾病预防控制中心
• 2:广西壮族自治区龙潭医院
• 3:广西壮族自治区疾病预防控制中心

摘要(Abstract)：

目的了解晚发现和非晚发现艾滋病病毒(HIV)感染者/艾滋病(AIDS)病人(简称HIV/AIDS病人)的配偶/固定性伴(简称配偶),在随访期1年内发生血清阳转的情况。方法对2010年1月1日到12月31日期间登记的HIV/AIDS病人的配偶建立观察队列,按是否是晚发现分组,统计基线调查后12个月内HIV/AIDS病人配偶的HIV血清阳转频率,并比较各分层因素HIV血清阳转优势比,计算晚发现和非晚发现两组随访1年内患者配偶血清阳转密度,明确晚发现和HIV血清阳转的关系。结果 1 649例HIV/AIDS病人中,晚发现HIV/AIDS病人占66.28%(1 093/1 649),非晚发现HIV/AIDS病人33.72%(556/1 649)。282例(17.10%)HIV/AIDS病人的配偶发生HIV血清阳转,晚发现病人配偶的血清阳转占总阳转患者比例为73.40%(207/282),非晚发现病人配偶的阳转比例为26.60%(75/282),两组比较差异有统计学意义(P=0.003);随访12个月时HIV/AIDS病人配偶的HIV血清阳转密度为30.97/100人年,其中晚发现病人的配偶为36.76/100(207/563.17)人年,非晚发现病人的配偶为21.58/100人年(75/347.47)。和非晚发现病人的配偶相比,晚发现病人配偶的HIV血清阳转在年龄、性别、职业、教育程度、感染途径等分层因素差异有统计学意义(P<0.05);晚发现HIV/AIDS病人配偶的血清转化密度最高是55~64岁组,30~40岁组是另一血清转化高峰。结论观察期1年内,广西HIV/AIDS病人配偶的HIV血清转化率较高,以55~64岁组为血清转化高峰,主要由晚发现患者导致。应提高HIV/AIDS病人早发现能力,和家庭计划生育干预、抗病毒治疗等干预措施相结合,减少HIV家庭内传播。

关键词(KeyWords)： 艾滋病病毒感染者/艾滋病病人;晚发现;配偶/固定性伴;血清阳转

Abstract:

Keywords:

基金项目(Foundation): 广西医疗卫生适宜技术开发与推广应用项目(S201682)~~

作者(Author): 江毅,李勇,覃善芳,郑志刚

DOI: 10.13419/j.cnki.aids.2018.06.08

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