人类免疫缺陷病毒感染者脑功能显像研究进展
蒲朝煜,陈燕
摘要(Abstract)：
<正>人类免疫缺陷病毒（HIV-1）及其后期的艾滋病（AIDS）本身和它们诱发的机会疾病（肿瘤、细菌与病毒感染、寄生虫病等）导致中枢神经系统（CNS）损害。中晚期患者CT及MRI（核磁共振成像）可见脑萎缩和/或占位病变,早期则无异常改变,而核素脑显像可在HIV-1感染的早期发现脑的异常血流和/或代谢改变。至少 50％的脑CT及 MRI 正常HIV-1（+）者中单光子发射型断层扫描仪（SPECT）或正电子发射型断层扫描仪（PET）显像脑内有异常变化[1～5]。核素脑显像可对HIV性脑损害进行鉴别诊断,为临床合理治疗提供依据。1HIV-1（+）者脑血流的变化 HIV-1（+）者脑血流变化有二种情况:局部血流下降,
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作者(Author): 蒲朝煜,陈燕
参考文献(References)：
- 1 Sacktor N, Prohovnik I, Van Heertum RL, et al. Cerebral single - photon emission computed tomography abnormalities in human immunodeficiency virus type 1 ~ infected gay men without congnitive impair-ment.Arch Neural, 1995,52(6) : 607-611
- 2 Rottenberg DA, Sidtis JJ, Strother SC, et al. Abnoemal cerebral glucose metabolism in HIV - 1 seropositive subjects with and without dementia.J Nucl Med, 1996,37(7):1 133-1 141
- 3 Iranzo A, Marti - Fabregas J, Domingo P, et al. Absence of thallium -201 brain uptake in progressive multifocal leukoencephalopathy in AIDS patients. Acta Neurol Scand, 1999,100:102-105
- 4 Wiseman MB, Sanchez JA, Buechel C, et al. Patterns of relative cerebral blood flow in minor congnitive motor disorder in human immunodeficiency virus infection. J Neuropsychiatry Clin Neurosci, 1999, 11 (2):222-233
- 5 Liow JS, Rehm K, Strother SC, et al. Comparison of voxel - and volume - of - interest - based analyses in FDG PET scans of HIV positive and healthy individuals.J Nucl Med, 2000, 41(4) :612-621
- 6 London ED, Bonson KR, Ernst M, et al. Brain imaging studies of con-caine abuse :implications for medication development. Crit Rev Neuro-biol, 1999,13(3) :227-242
- 7 De La Pena RC, Ketonen L, Villanueva - Meyer J. Imaging of brain tumors in AIDS patients by means of dual - isotope thallium - 201 and technetium - 99m sestamibi sing - photon emission tomography. EurJ Nucl Med, 1998,25(10): 1404-1 411
- 8 Naddaf SY, Akisik MF, Aziz M, et al. Comparison between 201T1 -chloride and 99Tc(m) - sestamibi SPECT brain imaging for differentiating intracranial lymphoma from non - malignant lesions in AIDS patients. Nucl Med Commun, 1998,19(1) :47-53
- 9 Castagna A, Cinque P, d' Amico A, et al. Evaluation of contrast - enhancing brain lesions in AIDS patients by means of Epstein - Barr virus detection in cerebrospinal fluid and 201 thallium single photon e-mission tomography. AIDS, 1997,11(12):1 522-1523
- 10 O' Dcherty MJ, Barrington SF, Campbell M, et al. J Nucl Med, 1997, 38(10):1575-1583
- 11 Depas G, Chiron C, Tardieu M, et al. Functional brain imaging in HIV - 1 - infected children born to seropositive mothers. J Nucl Med, 1995,36(12) :2 169-2 174
- 12 Ernst T, Itti E, Itti L, et al. Changes in cerebral metabolism are detected prior perfusion changes in early HIV - CMC: A coregistered (1)HMRS and SPECT study.J Magn Reson Imaging, 2000,12(6): 859-865
- 13 D'Amico A, Messa C, Castagna A, et al. Diagnostic accuracy and predictive value of 201T1 SPECT for the differntial diagnosis of cerebral lesions in AIDS patients. Nucl Med Communi, 1997,18:741 -751
- 14 Pierce MA, Johnson MD, Maciunas RJ, et al. Evaluating contrast -enhancing brain lesions in patients with AIDS by using positron emission tomography. Ann Intern Med, 1995,123(8) :594-598